| Name | U-47319 |
| Synonyms | U-47319 MK 7906 methyl-N-[[[[[(diethoxyplhosphiothioyl)isopropyl amino] tho] methyl amino]carbonyl]oxy]ethanimidothioate |
| CAS | 66996-10-9 |
| Molecular Formula | C12H26N3O4PS3 |
| Molar Mass | 403.521301 |
| Physical and Chemical Properties | The chemical quality product is crystalline. m.p.72~73℃ |
| Use | Use of this product is methomyl thiophosphonamide derivatives, its main use and methomyl, can be used for cotton, vegetables, fruit trees, rice and other functions, prevention and control of lepidopteran pests, Beetle and Diptera, the recommended content of 20% EC Diluted 1000 times, no plant damage. The control effect of resistant cotton aphid was basically the same as that of methomyl, and the control effect was better than that of methomyl, but the acute toxicity was lower than that of methomyl. |
Toxicity
acute oral LD50832mg/kg in male rats; Female rats have acute oral LD50325mg/kg. Compared with methomyl, it has greatly improved the safety of mammals.
production method
Preparation of O,O-Diethyl-N-isopropyl thiophosphonamide O,O-diethyl thiophosphonyl chloride reacts with isopropylamine in the presence of potassium carbonate. After the reaction, it is purified by vacuum distillation.
synthesis of foscarb 10.3g (0.1mol) of sulfur dichloride was dissolved in 50mL of tetrahydrofuran, 21.1g (0.1mol) O,O-diethyl-N-isopropyl thiophosphoramide, 9.6g (0.1mol) of triethylamine and 100mL of tetrahydrofuran were dripped under stirring, the temperature was controlled at -5~0 ℃, and the reaction was continued for 30min, then 16.2g (0.1mol) of methomyl and 0.1g of catalyst were added, and 9.6g (0.1mol) of triethylamine and 50mL of tetrahydrofuran were added. After dropping, the reaction was continued for 2 hours and the reaction was finished. Filter out the solid, wash with a small amount of tetrahydrofuran, the washing liquid and filtrate combined, decompressed to evaporate tetrahydrofuran, the remaining dissolved in 20mL toluene, washed with a small amount of water, and then decompressed to evaporate toluene, the remaining can be directly prepared emulsifiable concentrate. If it is dispersed and crystallized in petroleum ether, phosphacarb solid can be obtained, m.p.70.5 ~ 72 ℃, with a yield of about 80%.